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RSV nonstructural protein 1 (NS1) HDX LC-MS data

ABSTRACT: Raw liquid chromatography-mass spectrometry (LC-MS) datafiles acquired for hydrogen-deuterium exchange (HDX) of RSV nonstructural protein 1 (NS1)

INSTRUMENT(S):

ORGANISM(S): Human Respiratory Syncytial Virus 9320

SUBMITTER: Nicole Wagner

LAB HEAD: Michael L. Gross

PROVIDER: PXD054005 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	20171114_HDX_NS1_1to139_4deg_50uM_t0_002.raw	Raw
	20171114_HDX_NS1_1to139_4deg_50uM_t10_001.raw	Raw
	20171114_HDX_NS1_1to139_4deg_50uM_t10_002.raw	Raw
	20171114_HDX_NS1_1to139_4deg_50uM_t120_001.raw	Raw
	20171114_HDX_NS1_1to139_4deg_50uM_t120_002.raw	Raw

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1 - 5 of 14

Publications

Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25.

Kalita Parismita P Khatavkar Oam O Uwase Grace G Korshunova Yulia Y Hu Yuying Y Wagner Nicole D ND Xu Jian J Pan Jiehong J Nix Jay C JC Gross Michael L ML Brody Steven L SL Borek Dominika D Amarasinghe Gaya K GK Payton Jacqueline E JE Leung Daisy W DW

Nature communications 20250325 1

The Mediator complex facilitates interactions between transcription factors and RNA polymerase II, a process that is required for host gene transcription, including in response to viral infections. Among the many subunits in the Mediator complex, the MED25 subunit has been shown to be a target for viral activators during infection. Here we provide the molecular basis for the interaction between human respiratory syncytial virus (hRSV) nonstructural 1 protein (NS1) and the activator interaction d ...[more]

PMID: 40128225

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