Membrane proteomics in SHEP21N cells treated with NMTi
Ontology highlight
ABSTRACT: N-myristoyltransferase inhibitors (NMTi) are promising novel anti-cancer agents, including in MYCN-amplified neuroblastoma and Burkitt’s lymphoma, but a mechanistic rationale for targeted therapy is still poorly defined. A key function of N-myristoylation is to mediate membrane localisation. We therefore carried out membrane proteomics on the SHEP21N cell line +/- NMTi. Identification of PPIs between affected proteins via STRING allowed the identification of heavily affected biological nodes, including respiratory complex I. This study provides a mechanistic rationale for NMTi in MYCN-amplified neuroblastoma.
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Permanent Cell Line Cell
DISEASE(S): Neuroblastoma
SUBMITTER:
James Zhang
LAB HEAD: Edward W.
PROVIDER: PXD054008 | Pride | 2025-07-27
REPOSITORIES: Pride
ACCESS DATA