Proteomics

Dataset Information

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Membrane proteomics in SHEP21N cells treated with NMTi


ABSTRACT: N-myristoyltransferase inhibitors (NMTi) are promising novel anti-cancer agents, including in MYCN-amplified neuroblastoma and Burkitt’s lymphoma, but a mechanistic rationale for targeted therapy is still poorly defined. A key function of N-myristoylation is to mediate membrane localisation. We therefore carried out membrane proteomics on the SHEP21N cell line +/- NMTi. Identification of PPIs between affected proteins via STRING allowed the identification of heavily affected biological nodes, including respiratory complex I. This study provides a mechanistic rationale for NMTi in MYCN-amplified neuroblastoma.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

DISEASE(S): Neuroblastoma

SUBMITTER: James Zhang  

LAB HEAD: Edward W.

PROVIDER: PXD054008 | Pride | 2025-07-27

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
IA2907_zhangj1_13.raw Raw
IA2907_zhangj1_14.raw Raw
IA2907_zhangj1_15.raw Raw
IA2907_zhangj1_16.raw Raw
IA2907_zhangj1_17.raw Raw
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