Proteomics

Dataset Information

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Proteomics and microbiotas conjoint analysis in the nasal mucus: revelation of differences in immunological function in Manis javanica and Manis pentadactyla

ABSTRACT: This study aimed to investigate the differences in the immunity of Manis javanica and Manis pentadactyla through proteomics and microbiotas conjoint analysis.The nasal mucus of 10 pangolins (weight 5.71 kg ± 0.96 kg) was collected from the Wildlife Rescue Center of Shenzhen (Shenzhen City) and Guangdong Province (Guangzhou City). The pangolins from two different Wildlife Rescue Center were all in a healthy condition, although their feeding diets were not completely consistent.

INSTRUMENT(S): LCQ Classic

ORGANISM(S): Manis Javanica Manis Pentadactyla

TISSUE(S): Respiratory Mucus

SUBMITTER: Qing Han  

LAB HEAD: Jinping Chen

PROVIDER: PXD054168 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Y480A_FAIMS_TMT_HMK001_F1.raw Raw
Y480A_FAIMS_TMT_HMK001_F10.raw Raw
Y480A_FAIMS_TMT_HMK001_F2.raw Raw
Y480A_FAIMS_TMT_HMK001_F3.raw Raw
Y480A_FAIMS_TMT_HMK001_F4.raw Raw
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Publications

Proteomics and Microbiota Conjoint Analysis in the Nasal Mucus: Revelation of Differences in Immunological Function in <i>Manis javanica</i> and <i>Manis pentadactyla</i>.

Han Qing Q   Yu Yepin Y   Sun Hongbin H   Zhang Xiujuan X   Liu Ping P   Deng Jianfeng J   Hu Xinyuan X   Chen Jinping J  

Animals : an open access journal from MDPI 20240914 18

All eight pangolin species, especially captive <i>Manis pentadactyla</i>, are critically endangered and susceptible to various pathogenic microorganisms, causing mass mortality. They are involved in the complement system, iron transport system, and inflammatory factors. <i>M. pentadactyla</i> exhibited a higher abundance of opportunistic pathogens, <i>Moraxella</i>, which potentially evaded complement-mediated immune response by reducing C5 levels and counteracting detrimental effects through tr  ...[more]

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