Dataset Information

Mouse bone marrow-derived macrophages (BMDMs) loaded with atherogenic LDL

ABSTRACT: While aging is well established as an important risk factor for the development and progression of atherosclerosis, the underlying molecular mechanisms of this relationship remain poorly defined, and its role in atherosclerosis regression is unknown. We investigated the response of bone marrow-derived macrophages isolated from old and young mice to atherogenic aggregated LDL.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Cell, Macrophage Activation

DISEASE(S): Atherosclerosis

SUBMITTER: Sasha Singh

LAB HEAD: Mireille Ouimet

PROVIDER: PXD054290 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Service_20220202_Mireille_Ouimet_01.raw	Raw
	Service_20220202_Mireille_Ouimet_02.raw	Raw
	Service_20220202_Mireille_Ouimet_03.raw	Raw
	Service_20220202_Mireille_Ouimet_04.raw	Raw
	Service_20220202_Mireille_Ouimet_05.raw	Raw

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Publications

Age-Related Impairments in Immune Cell Efferocytosis and Autophagy Hinder Atherosclerosis Regression.

Boucher Dominique M DM Robichaud Sabrina S Lorant Victoria V Leon Jonathan S JS Suliman Issraa I Rasheed Adil A Susser Leah I LI Emerton Christina C Geoffrion Michele M De Jong Erica E Bowdish Dawn M E DME Aikawa Masanori M Aikawa Elena E Singh Sasha A SA Rayner Katey J KJ Ouimet Mireille M

Arteriosclerosis, thrombosis, and vascular biology 20250213 4

<h4>Background</h4>Aging is a well-established risk factor for the development and progression of atherosclerosis, but the molecular mechanisms underlying this relationship remain poorly defined, and its role in atherosclerosis regression is unknown. To uncover age-related alterations that may impair atherosclerosis regression, we investigated the response of young and old macrophages to atherogenic lipoproteins in vitro and in vivo.<h4>Methods</h4>Metabolic and proteomic studies were performed ...[more]

PMID: 39945065

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