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Proteomic Analysis of Spinal Dorsal Horn in Prior-Exercise Protection against Neuropathic Pain

ABSTRACT: Neuropathic pain (NP) is a complex and common chronic pain that affects millions of people worldwide. Previous studies showed that prior exercise protects against NP caused by nerve injury, but the mechanisms remain elusive. Therefore, this study aimed to identify the differentially expressed proteins (DEPs) involved in the process of protecting against NP by prior exercise and explore the underlying mechanisms through bioinformatic analysis.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Spinal Cord

SUBMITTER: Binglin Chen

LAB HEAD: Binglin Chen

PROVIDER: PXD054342 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	allPeptides.txt	Txt
	cci-01.raw	Raw
	cci-02.raw	Raw
	cci-03.raw	Raw
	cci-04.raw	Raw

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Publications

Proteomic analysis of spinal dorsal horn in prior exercise protection against neuropathic pain.

Chen Binglin B Guo Jiabao J Gong Chan C Zhu Chenchen C Wu Yang Y Wang Shengbo S Zheng Yili Y Lu Haixia H

Scientific reports 20250118 1

Neuropathic pain (NP) is a complex and prevalent chronic pain condition that affects millions of individuals worldwide. Previous studies have shown that prior exercise protects against NP caused by nerve injury. However, the underlying mechanisms of this protective effect remain to be uncovered. Therefore, the purpose of this study is to investigate how prior exercise affects protein expression in NP model rats and thus gain comprehensive insights into the molecular mechanisms involved. To achie ...[more]

PMID: 39827296

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