Dataset Information

Proteomic profiling of dogs diagnosed with anxiety disorder

ABSTRACT: Mass spectrometry is generally overlooked in the veterinary field despite the potential to yield significant and meaningful data with possible clinical implications. In this study, our team used mass spectrometry to investigate differences between the proteomic profile of a group of dogs diagnosed with an anxiety disorder and a group of control/healthy/non-anxious dogs, thus allowing for inferences to be made in the biological pathways that might be involved or affected in such disorders.

INSTRUMENT(S):

ORGANISM(S): Canis Familiaris (dog) (canis Lupus Familiaris)

TISSUE(S): Blood Plasma

SUBMITTER: Claudia Gaither

LAB HEAD: Marion Desmarchelier

PROVIDER: PXD054409 | Pride | 2025-07-28

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	EV002671_30SPD_C1_Top10.raw	Raw
	EV002672_30SPD_C2_Top10.raw	Raw
	EV002673_30SPD_C3_Top10.raw	Raw
	EV002674_30SPD_C4_Top10.raw	Raw
	EV002675_30SPD_C5_Top10.raw	Raw

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Publications

Plasma Proteomic Profiling of a Group of Anxious Dogs by LC-MS/MS: A Case-Control Study.

Gaither Claudia C Popp Robert R Borchers Christoph H CH Beaudry Francis F Desmarchelier Marion M

Proteomics. Clinical applications 20250704 4

<h4>Purpose</h4>Anxiety is the most common underlying cause of behavioral problems in dogs, which remain a top reason for relinquishment and euthanasia. Despite its high prevalence, anxiety is often underdiagnosed, partly due to a limited understanding of biological processes and absence of diagnostic biomarkers. Our study aims to address this knowledge gap.<h4>Experimental design</h4>Plasma from 10 anxious and 10 matched control dogs were analyzed following a label-free quantitation proteomics ...[more]

PMID: 40614171

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