Novel proteolysis targeting chimera (PROTAC) selectively targeting Leucine Zipper-bearing Kinase (LZK) limits oncogenic potential of head and neck cancers.

ABSTRACT: Head and neck squamous cell carcinomas (HNSCC) are aggressive epithelial tumors with a low and unchanged 50% 5-year survival rate. MAP3K13 gene encoding Leucine Zipper-bearing Kinase (LZK) is often amplified in HNSCC patients and can be an oncogenic driver for tumorigenesis. In order to reduce catalytic and non-catalytic functions of LZK we synthetized novel, potent and selective degrader of LZK protein using proteolysis targeting chimera technology. We confirmed efficiency and specificity of our PROTAC by Liquid chromatography-mass spectrometry analysis. The dataset was obtained with the support of the National Science Centre Sonata Bis grant (UMO-2021/42/E/NZ5/00227).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Head And Neck Squamous Cell Carcinoma Cell

SUBMITTER: Remigiusz Serwa  

LAB HEAD: John Brognard

PROVIDER: PXD054481 | Pride | 2026-02-16

REPOSITORIES: Pride