Phosphoproteomics analysis of TAMs with NEK2 overexpression

ABSTRACT: NEK2 is considered a key factor in the maintenance of development and function of B cells in multiple myeloma (MM). Importantly, we previously demonstrated that PD-L1 is a substrate of NEK2, and combinatorial inhibition of NEK2 and PD-L1 largely improves the therapeutic efficacy of pancreatic cancer in pre-clinical models. But the expression and function of NEK2 in HCC-related TAMs have not yet been studied. This analysis revealed changes in the proteome due to the overexpression of NEK2 in TAMs, providing a valuable reference for further functional investigations.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Xiaozhen Zhang  

LAB HEAD: Xiaozhen Zhang

PROVIDER: PXD054708 | Pride | 2025-05-26

REPOSITORIES: Pride