Evidence of focusing the MHC class I immunopeptidome by tapasin
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ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Suspension Culture
SUBMITTER: 
Patricia Illing
LAB HEAD: Anthony W Purcell
PROVIDER: PXD054743 | Pride | 2025-06-02
REPOSITORIES: Pride
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Publications
Evidence of focusing the MHC class I immunopeptidome by tapasin.
Darley Rachel R Illing Patricia T PT Duriez Patrick P Bailey Alistair A Purcell Anthony W AW van Hateren Andy A Elliott Tim T
Frontiers in immunology 20250508
Major Histocompatibility Complex class I (MHC-I) molecules bind and present peptides to cytotoxic T cells, protecting against pathogens and cancer. MHC-I is highly polymorphic and each allotype is promiscuous, and capable of binding a unique and diverse repertoire of peptide ligands. The peptide editing chaperone tapasin optimizes this allotype specific repertoire of peptides, resulting in the selection of high affinity peptides. MHC-I allotypes differ in the extent they engage tapasin. This sug ...[more]
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