Dataset Information

INFECTION-DRIVEN PROTEOMIC SIGNATURES IN IMMUNE CELL–DERIVED EXTRACELLULAR VESICLES REFLECT HEMORRHAGIC STROKE OUTCOME

ABSTRACT: Infectious complications negatively impact outcome of patients with intracerebral hemorrhage (ICH). Identification of biomarkers of the mechanisms by which infection may modify the course of stroke could help predict the clinical evolution, and the search for personalized treatments. Investigating the content of immune cell-derived extracellular vesicles (EVs), may provide relevant information in this regard. In this study we investigate the differential expression of proteins in circulating EVs from immune cells in patients with ICH according to the occurrence of infections and to outcomes. The protein content of the immune cells -derived EVs was analyzed by data independent acquisition (SWATH-MS) mass spectrometry. Differential abundance between groups was defined as fold-change ≥2 or ≤0.5 and p≤0.05.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, T Cell, Monocyte, Blood

DISEASE(S): Intracerebral Hemorrhage

SUBMITTER: Susana Bravo

LAB HEAD: Susana B

PROVIDER: PXD054777 | Pride | 2026-01-26

REPOSITORIES: Pride

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Publications

Infection-driven proteomic signatures in immune cell-derived extracellular vesicles reflect hemorrhagic stroke outcome.

Laso-García Fernando F Alonso-López Elisa E Piniella Dolores D Díez-Tejedor Exuperio E Gómez-de Frutos Mari Carmen MC Casado-Fernández Laura L Otero-Ortega Laura L López-Molina Mari Paz MP Gallego-Ruiz Rebeca R Pozo-Novoa Javier J Calzado-González Ángela Á Díaz-Gamero Nerea N Román-San Martín Alicia A Bravo Susana S Barderas Rodrigo R Docando Félix F Fuentes Blanca B Juárez-Martín Belén B Alonso de Leciñana María M Gutiérrez-Fernández María M

Journal of neuroinflammation 20251204 1

BACKGROUND: Analyzing the content of immune cell-derived extracellular vesicles (EVs) may reveal biomarkers that elucidate the mechanisms through which infection negatively affects outcomes in patients with intracerebral hemorrhage (ICH). METHODS: A prospective observational study in patients with acute ICH classified by the occurrence of in-hospital infection within 7 days and outcomes at 6 months, good outcome defined as an improvement of > 10 points or > 50% in NIHSS score and a mRS score 0–2 ...[more]

PMID: 41345658

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