Dataset Information
HDX-MS analysis of TDP-43 with RNA oligonucleotides
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Antonio Calabrese
LAB HEAD: Antonio Calabrese
PROVIDER: PXD054930 | Pride | 2025-05-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| HEPES_finalised.DnX | Other | |||
| Kphos_finalised1.DnX | Other | |||
| fbsjrau_220529G_tdp_wt_0.raw.zip | Raw | |||
| fbsjrau_220529G_tdp_wt_2.raw.zip | Raw | |||
| fbsjrau_220529G_tdp_wt_4.raw.zip | Raw |
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Publications
Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Mechanistic Insights into RNA Oligonucleotide-Mediated Inhibition of TDP-43 Aggregation.
Journal of the American Chemical Society 20241129 49
Deposits of aggregated TAR DNA-binding protein 43 (TDP-43) in the brain are associated with several neurodegenerative diseases. It is well established that binding of RNA/DNA to TDP-43 can prevent TDP-43 aggregation, but an understanding of the structure(s) and conformational dynamics of TDP-43, and TDP-43-RNA complexes, is lacking, including knowledge of how the solution environment modulates these properties. Here, we address this challenge using hydrogen-deuterium exchange-mass spectrometry. ...[more]