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Additional roles of protamine kinase SRPK1 in sperm development

ABSTRACT: In the testis, Serine/arginine protein kinase 1 (SRPK1) and isoform 2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP1γ) are essential proteins involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility. The aim of this study was to expand the knowledge on the molecular role of these phosphorylation-modulating proteins through the identification of novel partners in the testis that could support additional roles in proper testicular function. We identified the list of proteins associated with the kinase SRPK1 and the phosphatase PP1γ in adult mouse testis, pointing out additional roles of both proteins regulating essential processes for a proper sperm differentiation.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis

SUBMITTER: Marjorie Leduc

LAB HEAD: Julie Cocquet

PROVIDER: PXD054959 | Pride | 2026-03-31

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	JuCO210216_SRPK1_IgG_IP_1_C39746_RO12_1_1391.d.7z	Other
	JuCO210216_SRPK1_IgG_IP_2_C39748_RO14_1_1395.d.7z	Other
	JuCO210216_SRPK1_SRPK1_IP_1_C39745_RO11_1_1389.d.7z	Other
	JuCO210216_SRPK1_SRPK1_IP_2_C39747_RO13_1_1393.d.7z	Other
	JuCO210617__IP_SRPK1_XL_A41971_GA1_1_3008.d.7z	Other

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Additional roles of phosphatase PP1γ in sperm development

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