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Additional roles of phosphatase PP1γ in sperm development

ABSTRACT: In the testis, Serine/arginine protein kinase 1 (SRPK1) and isoform 2 of Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP1γ) are essential proteins involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility. The aim of this study was to expand the knowledge on the molecular role of these phosphorylation-modulating proteins through the identification of novel partners in the testis that could support additional roles in proper testicular function. We identified the list of proteins associated with the kinase SRPK1 and the phosphatase PP1γ in adult mouse testis, pointing out additional roles of both proteins regulating essential processes for a proper sperm differentiation.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Testis

SUBMITTER: Marjorie Leduc

LAB HEAD: Julie Cocquet

PROVIDER: PXD054960 | Pride | 2026-03-31

REPOSITORIES: Pride

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			Action	DRS
	JuCO210617__IP1_PP1gamma_XL_A41974_GA4_1_3014.d.7z	Other
	JuCO210617__IP1_Sample_X_A41973_GA3_1_3012.d.7z	Other
	JuCO210617__IP1_ms_IgG_XL_A41975_GA5_1_3016.d.7z	Other
	JuCO210617__IP2_PP1gamma_XL_A41977_GA7_1_3020.d.7z	Other
	JuCO210617__IP2_Sample_X_A41976_GA6_1_3018.d.7z	Other

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Additional roles of protamine kinase SRPK1 in sperm development

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