DNMT3A regulates megakaryocyte-biased HSC fate decisions

ABSTRACT: We characterized the role of the DNA methyltransferase DNMT3A in the fate decisions of murine megakaryocyte-biased HSCs and in the differentiation of megakaryocytes and platelets. In this experiment, we isolated washed platelets from 4 WT and 4 Dnmt3a+/– germline mice (2 males and 2 females per group) and subjected them to proteomic analysis by mass-spectrometry. We sought to identify changes at the protein level that occur in platelets due to aberrant DNA methylation during the differentiation of upstream hematopoietic cells.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Platelet

SUBMITTER: Antrix Jain  

LAB HEAD: Margaret A. Goodel

PROVIDER: PXD055265 | Pride | 2025-06-09

REPOSITORIES: Pride