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Characterisation of CASQ2 knockout cardiac organoid model

ABSTRACT: Cardiac maturation is an important developmental phase where there are profound biological and functional changes after birth in mammals. Herein, we use our profiling of human heart maturation in vivo to identify key drivers of maturation in our human cardiac organoid (hCO) model. In this dataset, we exemplified the applicability of our mature organoids in modelling cardiac contraction. Three calsequesterin-2 (CASQ2) knock out (-/-) hCO lines were generated to demonstrate the effect of sarcoplasmic reticulum Ca2+ leakiness on contraction. In this dataset, we evaluate the proteomic remodelling induced by CASQ2 (-/-, n=3) versus CTRL mature hCOs (n=1).

INSTRUMENT(S): Q Exactive HF, Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Heart, Embryonic Stem Cell

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Harley Robinson

LAB HEAD: James Hudson

PROVIDER: PXD055266 | Pride | 2025-04-17

REPOSITORIES: Pride

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			Action	DRS
	20240816_CASQ2_CTRL.raw	Raw
	20240816_CASQ2_KO_1.raw	Raw
	20240816_CASQ2_KO_2.raw	Raw
	20240816_CASQ2_KO_3.raw	Raw
	CASQ2_library.predicted.speclib	Other

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