The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi

ABSTRACT: We quantified the proteome of Dsc complex mutants (tul1gld1) and ESCRT mutants (vps4). Therefore we used stable isotope labeling with amino acids in cell culture (SILAC) to identify changes in the membrane proteome of tul1gld1orvps4 cells relative to WT cells or gld1 cells (labeled with “heavy” [13C6,15N2]-L-lysine).

INSTRUMENT(S):

ORGANISM(S): Candida Albicans (yeast)

SUBMITTER: Leopold Kremser  

LAB HEAD: David Teis

PROVIDER: PXD055553 | Pride | 2025-05-07

REPOSITORIES: Pride