Fat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.

ABSTRACT: Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We have previously used the laser microdissection and mass spectrometry (LMD/MS) to search for target antigens in PLA2R-negative MN. In this study, we used LMD/MS to search for the target antigen(s) in de novo MN. Our studies identified target antigen FAT1 in de novo MN when it is associated with concurrent antibody mediated rejection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Kidney

SUBMITTER: Benjamin Madden  

LAB HEAD: Sanjeev Sethi M.D. Ph.D.

PROVIDER: PXD055559 | Pride | 2024-10-22

REPOSITORIES: Pride