Dataset Information

Proteomics of serotonergic autoregulation

ABSTRACT: Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with depression to the most common antidepressive drugs inhibiting the serotonin transporter (SERT), a molecule responsible for the reuptake of serotonin and therefore for its quick removal from the synaptic cleft. However, the signaling pathways involved in autoregulation and the molecular alterations induced by serotonin on its autoreceptors are yet unclear. We aim at analysing changes in levels of proteins induced by longterm changes of serotonin levels in Raphe nuclei of mice with low and elevated serotonin release in the brain to reveal the signaling pathways involved in the autoregulation of serotonergic neurons.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Raphe Nuclei

DISEASE(S): Mental Depression

SUBMITTER: Oliver Popp

LAB HEAD: Natalia Alenina

PROVIDER: PXD055579 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	Animal_20191211_OP_MMtmt_AGBader_Proteome_fr01.raw	Raw
	Animal_20191211_OP_MMtmt_AGBader_Proteome_fr02.raw	Raw
	Animal_20191211_OP_MMtmt_AGBader_Proteome_fr03.raw	Raw
	Animal_20191211_OP_MMtmt_AGBader_Proteome_fr04.raw	Raw
	Animal_20191211_OP_MMtmt_AGBader_Proteome_fr05.raw	Raw

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Publications

Hyperphenylalaninemia and serotonin deficiency in Dnajc12-deficient mice.

Cao Yunqing Y Popp Oliver O Milani Niccolo N Qadri Fatimunnisa F Kühn Ralf R Mertins Philipp P Bader Michael M Alenina Natalia N

Communications biology 20241218 1

Serotonin exerts numerous neurological and physiological actions in the brain and in the periphery. It is generated by two different tryptophan hydroxylase enzymes, TPH1 and TPH2, in the periphery and in the brain, respectively, which are members of the aromatic amino acid hydroxylase (AAAH) family together with phenylalanine hydroxylase (PAH), degrading phenylalanine, and tyrosine hydroxylase (TH), generating dopamine. In this study, we show that the co-chaperone DNAJC12 is downregulated in ser ...[more]

PMID: 39695187

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