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SChLAP1 pulldown, Hargrove Lab Duke University

ABSTRACT: Test v Control IP of SChLAP1 analyzed by bottoms-up proteomics approach on Orbitrap Astral.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Erik Soderblom

LAB HEAD: Amanda Hargrove,

PROVIDER: PXD055741 | Pride | 2025-09-08

REPOSITORIES: Pride

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			Action	DRS
	20240621_073009_10492_james_062124_Report_peptide.tsv	Tabular
	ID114158_01_SPD30_OA10034_10492_061824.raw	Raw
	ID114159_01_SPD30_OA10034_10492_061824.raw	Raw
	ID114160_01_SPD30_OA10034_10492_061824.raw	Raw
	ID114161_01_SPD30_OA10034_10492_061824.raw	Raw

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Publications

Structural analysis of the lncRNA SChLAP1 reveals protein binding interfaces and a conformationally heterogenous retroviral insertion.

Falese James P JP McFadden Emily J EJ D'Inzeo Christopher A CA Hargrove Amanda E AE

RNA (New York, N.Y.) 20250818 9

The lncRNA second chromosome locus associated with prostate 1 (SChLAP1) was previously identified as a predictive biomarker and potential driver of aggressive prostate cancer. Recent work suggested that SChLAP1 may bind the SWI/SNF chromatin remodeling complex to promote prostate cancer metastasis, though the exact role of SWI/SNF recognition is debated. To date, there are no detailed biochemical studies of <i>apo</i> SChLAP1 or SChLAP1:protein complexes. Herein, we report the first secondary st ...[more]

PMID: 40500149

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