Proteomics

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Proteomic profiling of anterior pituitary of bull calves offered either a high or moderate plane of nutrition in early life

ABSTRACT: Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in bull calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in bulls, with the dynamics of gonadotropin pulsatility within the anterior pituitary gland, in particular, central to final sexual maturity. However, the precise molecular mechanisms regulating the influence of metabolic status on this signalling axis in bull calves is yet to be fully elucidated. The objective of this study was to determine the effect of an enhanced plane of nutrition during early life, up to 12 weeks of age, on the anterior pituitary gland proteome of bull calves. Bull calves were offered either a high or moderate plane of nutrition.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Bos Taurus (bovine)

TISSUE(S): Brain

SUBMITTER: Tara Carthy  

LAB HEAD: David Kenny

PROVIDER: PXD055940 | Pride | 2025-07-14

REPOSITORIES: Pride

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Source:
Action DRS
20190927_002_S204082_AP27848_Group_1.raw Raw
20190927_003_S204089_AP37840_Group_1.raw Raw
20190927_004_S204090_AP77860_Group_1.raw Raw
20190927_005_S204094_AP37865_Group_2.raw Raw
20190927_007_S204100_AP97854_Group_2.raw Raw
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Publications

Effect of enhanced early life nutrition on the molecular regulation of anterior pituitary function in Holstein Friesian bull calves.

Keogh K K   Coen S S   Lonergan P P   Fair S S   Kenny D A DA  

Scientific reports 20250701 1

Enhanced early-life nutrition is known to induce precocious reproductive development in the bull calf, mediated through gonadotropin releasing hormone (GnRH) stimulated gonadotropin pulsatility in the anterior pituitary gland. The objective of this study was to evaluate transcriptomic and proteomic responses within the anterior pituitary of Holstein-Friesian bull calves offered different planes of nutrition during early life. Bull calves were offered either a high (HI; n = 15) or moderate (MOD;  ...[more]

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