Ontology highlight
ABSTRACT:
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Mus Musculus (mouse)
SUBMITTER: Joakim Bastrup
LAB HEAD: Thomas Jepps
PROVIDER: PXD055964 | Pride | 2025-05-07
REPOSITORIES: Pride
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Rippe Catarina C Bastrup Joakim Armstrong JA Holmberg Johan J Kawka Katarzyna K Arévalo Martinez Marycarmen M Albinsson Sebastian S Jepps Thomas A TA Swärd Karl K
The Journal of biological chemistry 20250312 4
Age is a critical determinant of arterial disease, including aneurysm formation. Here, to understand the impact of aging on the arterial transcriptome, we leveraged RNA-sequencing data to define transcripts that change with advancing age in human arteries. Among the most repressed transcripts in aged individuals were those that are relevant for actomyosin structure and organization, including both myosin light chain kinase (MYLK) and smooth muscle γ-actin (ACTG2). This was associated with a redu ...[more]