Dataset Information

Declining activity of serum response factor in aging arteries in relation to aortic aneurysm initiation and progression

ABSTRACT: public RNA-sequencing data were leveraged to define how the transcriptome of healthy human arteries remodels with age, uncovering both known and novel age-dependent processes. We demonstrate for the first time that the SRF regulon is gradually depleted in the aging arterial wall, and that this, when mimicked by genetic SRF depletion in young mice, impairs contractility and elicits aortic remodeling and mucoid extracellular matrix accumulation which are hallmarks of aneurysmal disease. Moreover, aortic reduction of SRF mimics a molecular signature of Ang II treatment, an intervention that causes aortic aneurysm in and by itself.

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Joakim Bastrup

LAB HEAD: Thomas Jepps

PROVIDER: PXD055964 | Pride | 2025-05-07

REPOSITORIES: Pride

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Declining activity of serum response factor in aging aorta in relation to aneurysm progression.

Rippe Catarina C Bastrup Joakim Armstrong JA Holmberg Johan J Kawka Katarzyna K Arévalo Martinez Marycarmen M Albinsson Sebastian S Jepps Thomas A TA Swärd Karl K

The Journal of biological chemistry 20250312 4

Age is a critical determinant of arterial disease, including aneurysm formation. Here, to understand the impact of aging on the arterial transcriptome, we leveraged RNA-sequencing data to define transcripts that change with advancing age in human arteries. Among the most repressed transcripts in aged individuals were those that are relevant for actomyosin structure and organization, including both myosin light chain kinase (MYLK) and smooth muscle γ-actin (ACTG2). This was associated with a redu ...[more]

PMID: 40081573

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