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The bacterial toxicity effect of HA on graphene

ABSTRACT: The bacterial toxicity effect and mechanism of HA on graphene

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

TISSUE(S): Cell Culture

SUBMITTER: jin zeng

LAB HEAD: xuejiao Zhang

PROVIDER: PXD056079 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	TEclipse_FAIMS_LFQ_DBPSN060_20231116_P_1212_PeptideGroups.txt	Txt
	TEclipse_FAIMS_LFQ_DBPSN060_20231116_P_1212_Proteins.txt	Txt
	TEclipse_FAIMS_LFQ_DBPSN060_CK_1.raw	Raw
	TEclipse_FAIMS_LFQ_DBPSN060_CK_2.raw	Raw
	TEclipse_FAIMS_LFQ_DBPSN060_CK_3.raw	Raw

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Publications

Mechanistic evaluation of enhanced graphene toxicity to Bacillus induced by humic acid adsorption.

Zhang Xuejiao X Zeng Jin J White Jason C JC Li Fangbai F Xiong Zhiqiang Z Zhang Siyu S Xu Yuze Y Yang Jingjing J Tang Weihao W Zhao Qing Q Wu Fengchang F Xing Baoshan B

Nature communications 20250103 1

The extensive application of graphene nanosheets (GNSs) has raised concerns over risks to sensitive species in the aquatic environment. The humic acid (HA) corona is traditionally considered to reduce GNSs toxicity. Here, we evaluate the effect of sorbed HA (GNSs-HA) on the toxicity of GNSs to Gram positive Bacillus tropicus. Contrary to previous data, GNSs-HA exhibits greater toxicity compared to GNSs. Multi-omics combined with sensitive bioassays and electrochemical methods reveals GNSs disrup ...[more]

PMID: 39753547

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The effect of HA on the bacterial toxicity of GNSs

Project description:Since its discovery in 2004, graphene nanosheets (GNSs) have been extensively studied for their unique properties that enabe multiple applications, including in electronics, catalysis, biomedicine, and environmental fields.The global graphene market is predicted to rise from $620 million in 2020 to $1.48 billion in 2025.3 However, with the increasing production and widespread application of GNSs, there is also an increased likelihood of GNSs-based waste entering the aquatic environment, raising cocners over potential environmental damage.

2025-05-06 | PXD043749 | Pride

Extremely low frequency electromagnetic fields enhance neuronal differentiation of human mesenchymal stem cells on graphene-based substrate

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RNAseq of primary human monocyte derived macrophages (MDM) and differentiated THP-1 macrophages exposed to graphene-related (nano)materials (GRMs)

Project description:Occupational and consumer exposure to GRMs will increase but their impact on human health is still largely unknown. We sought to perform a transcriptome comparison of the bioresponses of MDM and THP-1 macrophages exposed to 5 or 20 µg/ml graphene oxide (GO) or graphene nanoplatelets (GNP) for 6 and 24 h to capture early and more persistent acute responses. Cristalline silica (DQ) was included as immunotoxic reference material.

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A transcriptomic overview of lung and liver changes one day after pulmonary exposure to graphene and graphene oxide

Project description:This study investigates transcriptomic differences in the lung and liver after pulmonary exposure to two Graphene based materials with similar physical properties, but different surface chemistry. Female C57BL/6 mouse were exposed by a single intratracheal instillation of 0, 18, 54 or 162 μg/mouse of graphene oxide (GO) or reduced graphene oxide (rGO). Pulmonary and hepatic transcriptional changes were compared to identify commonly and uniquely perturbed functions and pathways by GO and rGO. These changes were then related to previously analyzed endpoints. GO exposure induced more differentially expressed genes, affected more functions, and perturbed more pathways compared to rGO, both in the lung and liver.

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Project description:graphene-soil Raw sequence reads

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Extremely low frequency electromagnetic fields enhance neuronal differentiation of human mesenchymal stem cells on graphene-based substrate

2014-12-23 | GSE64416 | GEO

Single-cell mass cytometry reveals the impact of graphene nanomaterials with human primary immune cells

Project description:The genome-wide transcriptome analysis highlight the increased biocompatibility on immune cells of graphene functionalized with amino groups (NH2) compared with graphene oxide (GO); reducing the cell metabolism disfunction. Moreover, GONH2 was found to polarizes T-cell and monocyte activation toward a T helper-1/M1 immune response.

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Graphene Oxide Substrate Promotes Neurotrophic Factor Secretion and Survival of Human Schwann-Like Adipose Mesenchymal Stromal Cells - RNAseq

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2021-03-08 | E-MTAB-10078 | biostudies-arrayexpress

Expression data MCF-7 Breast cancer cells with Graphene Oxide and Graphene nitrite Treatments

Project description:Breast cancer is one of the fatal diseases, Graphene has a property that can be used for Imaging and Therapy. Global gene expression changes leading to these changes were investigated presently in Breast cancer subtypes. The pathological staging of the cancers is compared to global gene expression profiles. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

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Project description:Graphene has been selected as a candidate for synthetic feeder-free culture substrate guiding human/mouse multipotent stem cell lineage specification, and culturing pluripotent stem cells in a number of studies. However, conventional graphene is not an ideal biomaterial to maintain the pluripotency of human pluripotent stem cells (hPSC) including hESCs/hiPSCs due to its intrinsic hydrophobicity and relatively flat surface topography. Here, we applied morphology-controlled nanocrystalline graphene (NG) coating onto the culture substrates via diffusion-associated synthesis (DAS) process and cultivated hPSCs. It is found that enhanced hydrophilicity and controlled surface roughness of DAS-NG enabled tight focal adhesion of hPSCs onto the DAS-NG coated culture substrate and retained pluripotency for over 2 weeks. It is also found hPSCs grown on DAS-NG shared comparable global gene expression profile with hPSCs grown on mouse embryonic fibroblast (MEF). Importantly, the similarities in cell adhesion gene expression between hPSCs grown on DAS-NG and hPSCs on MEF suggest DAS-NG may provide comparable physical cues with MEF for sustaining pluripotency. Taken together, our findings show a new reliable method for culturing hPSCs in feeder-free condition using DAS-graphene. Human iPSCs and human ESC H9 were seeded onto DAS-NG coated glass, ITO or QU, CVD-grown graphene coated glass, uncoated glass and mitomycin-C treated CF1. Human pluripotent stem cells seeded on each culture substrate were cultured in human embryonic stem cell medium composed of knockout DMEM (GIBCO-10829) supplemented with 20% knockout serum replacement (GIBCO-10828), 1mM L-glutamine, 1% penicillin/streptomycin (PAA-P11-010), 1% MEM-non essential amino acid (PAA-M11-003), 0.1mM beta-mercaptoethanol, and 5ng/ml human basic fibroblast growth factor.

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