Dataset Information
Total Synthesis and Target Identification of Marine Cyclopiane Diterpenes
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Macrophage
DISEASE(S): Leukemia
SUBMITTER: 
Li Tian
LAB HEAD: Li houhua
PROVIDER: PXD056084 | Pride | 2025-05-07
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| JS_IRGM1_CC_1.raw | Raw | |||
| JS_IRGM1_CC_2.raw | Raw | |||
| JS_IRGM1_CC_3.raw | Raw | |||
| checksum.txt | Txt | |||
| peptide_1.txt | Txt |
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Publications
Total synthesis and target identification of marine cyclopiane diterpenes.
Nature communications 20241230 1
Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecu ...[more]
