Total Synthesis and Target Identification of Marine Cyclopiane Diterpenes

ABSTRACT: We report our synthetic and chemical proteomics studies of marine cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target using an alkyne-tagged conidiogenone C-derived probe.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Macrophage

DISEASE(S): Leukemia

SUBMITTER: Li Tian  

LAB HEAD: Li houhua

PROVIDER: PXD056084 | Pride | 2025-05-07

REPOSITORIES: Pride