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Total Synthesis and Target Identification of Marine Cyclopiane Diterpenes

ABSTRACT: We report our synthetic and chemical proteomics studies of marine cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target using an alkyne-tagged conidiogenone C-derived probe.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Macrophage

DISEASE(S): Leukemia

SUBMITTER: Li Tian

LAB HEAD: Li houhua

PROVIDER: PXD056084 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	JS_IRGM1_CC_1.raw	Raw
	JS_IRGM1_CC_2.raw	Raw
	JS_IRGM1_CC_3.raw	Raw
	checksum.txt	Txt
	peptide_1.txt	Txt

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Publications

Total synthesis and target identification of marine cyclopiane diterpenes.

Li Tian T Jiang Shan S Dai Yuanhao Y Wu Xia X Guo Huihui H Shi Liang L Sang Xueli X Ren Li L Wang Jie J Shi Lili L Zhou Wenming W Li Houhua H Hao Hong-Dong HD

Nature communications 20241230 1

Marine cyclopianes are a family of diterpenoid with novel carbon skeleton and diverse biological activities. Herein, we report our synthetic and chemical proteomics studies of cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target. Our asymmetric synthesis commences from Wieland-Miescher ketone and features a sequential intramolecu ...[more]

PMID: 39738095

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