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S100P OE cells Proteome LC-MS/MS

ABSTRACT: Immunoprecipitation samples for LC-MS/MS used to find binding proteins with S100P.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Min Yang

LAB HEAD: Bo Chu

PROVIDER: PXD056171 | Pride | 2025-05-07

REPOSITORIES: Pride

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Publications

S100P is a ferroptosis suppressor to facilitate hepatocellular carcinoma development by rewiring lipid metabolism.

Yang Min M Cui Weiwei W Lv Xiaoting X Xiong Gaozhong G Sun Caiyu C Xuan Haocheng H Ma Wei W Cui Xiuling X Cheng Yeping Y Han Lihui L Chu Bo B

Nature communications 20250108 1

Ferroptosis is a newly identified programmed cell death induced by iron-driven lipid peroxidation and implicated as a potential approach for tumor treatment. However, emerging evidence indicates that hepatocellular carcinoma (HCC) cells are generally resistant to ferroptosis and the underlying molecular mechanism is poorly understood. Here, our study confirms that S100 calcium binding protein P (S100P), which is significantly up-regulated in ferroptosis-resistant HCC cells, efficiently inhibits ...[more]

PMID: 39779666

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