Dataset Information

Mass spac of IFNb stimulated WT, PFDN3 KO and PFDN4 KO HEK293 cells

ABSTRACT: We profiled the global cellular proteome of WT, PFDN3 knockout, and PFDN4 knockout cells using label-free quantification (LFQ) mass spectrometry.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Kidney

SUBMITTER: Yinxing Zhu

LAB HEAD: Siyuan Ding

PROVIDER: PXD056198 | Pride | 2026-02-09

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20220720_bkc_23-0070_Ding_Zhu_PFDN3-KO-1.raw	Raw
	20220720_bkc_23-0070_Ding_Zhu_PFDN3-KO-1_r2.raw	Raw
	20220720_bkc_23-0070_Ding_Zhu_PFDN3-KO-1_r2.xlsx	Xlsx
	20220720_bkc_23-0070_Ding_Zhu_PFDN3-KO-2.raw	Raw
	20220720_bkc_23-0070_Ding_Zhu_PFDN3-KO-2_r2.raw	Raw

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Publications

Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3.

Zhu Yinxing Y Song Yanhua Y Kumar Dilip D Jackson Peter K PK Prasad B V Venkataram BVV Ding Siyuan S

Nature communications 20250829 1

Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood. By conducting tandem-affinity purification coupled with high-resolution mass spectrometry, we identify the prefoldin complex as the top cellular binding partner of VP3. Rotavirus infection is significantly enhanced in prefoldin subuni ...[more]

PMID: 40883306

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