Dataset Information

Surface biotinylation HEK293 Cx32

ABSTRACT: The surface expression of Cx32 and other proteins was assessed after transfection.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Dina Schuster

LAB HEAD: Volodymyr M. Korkhov

PROVIDER: PXD056242 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20240924_191224_dschuster.sne	Other
	20240924_191224_dschuster_Report_protein_quant.csv	Csv
	20240924_191224_dschuster_Report_protein_quant.log.txt	Txt
	20240924_191224_dschuster_Report_protein_quant.params	Other
	20240924_191224_dschuster_Report_protein_quant.setup.txt	Txt

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Publications

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate.

Lavriha Pia P Han Yufei Y Ding Xinyue X Schuster Dina D Qi Chao C Vaithia Anand A Picotti Paola P Korkhov Volodymyr M VM

PloS one 20241231 12

Gap junction intercellular communication (GJIC) between two adjacent cells involves direct exchange of cytosolic ions and small molecules via connexin gap junction channels (GJCs). Connexin GJCs have emerged as drug targets, with small molecule connexin inhibitors considered a viable therapeutic strategy in several diseases. The molecular mechanisms of GJC inhibition by known small molecule connexin inhibitors remain unknown, preventing the development of more potent and connexin-specific therap ...[more]

PMID: 39739741

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