Dataset Information

Global acetylomic changes induced by HDAC10 inhibitor in acute lymphoid leukemia cells

ABSTRACT: A SILAC-based quantitative acetylomics experiment was performed to study the changes in lysine acetylation status induced by the HDAC10 inhibitor PZ48 in RS4-11 acute lymphoid leukemia cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Cell Suspension Culture

DISEASE(S): Acute Leukemia

SUBMITTER: Jia-Xuan Chen

LAB HEAD: Oliver Krämer

PROVIDER: PXD056251 | Pride | 2025-06-01

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	20231012_SFB1_EXT_CF_0946_A_hs_IP_SIL_120.raw	Raw
	20231012_SFB1_EXT_CF_0946_B_hs_IP_SIL_120.raw	Raw
	20231012_SFB1_EXT_CF_0946_C_hs_IP_SIL_120.raw	Raw
	20231012_SFB1_EXT_CF_0946_D_hs_IP_SIL_120.raw	Raw
	20231012_SFB1_EXT_CF_0946_E_hs_IP_SIL_120.raw	Raw

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Publications

The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells.

Mieland Andreas O AO Petrosino Giuseppe G Dejung Mario M Chen Jia-Xuan JX Fulzele Amitkumar A Mahmoudi Fereshteh F Tu Jia-Wey JW Mustafa Al-Hassan M AM Zeyn Yanira Y Hieber Christoph C Bros Matthias M Schnöder Tina M TM Heidel Florian H FH Najafi Sara S Oehme Ina I Hofmann Ilse I Schutkowski Mike M Hilscher Sebastian S Kosan Christian C Butter Falk F Bhatia Sanil S Sippl Wolfgang W Krämer Oliver H OH

Leukemia 20250429 7

Histone deacetylases (HDACs) comprise a family of 18 epigenetic modifiers. The biologically relevant functions of HDAC10 in leukemia cells are enigmatic. We demonstrate that human cultured and primary acute B cell/T cell leukemia and lymphoma cells require the catalytic activity of HDAC10 for their survival. In such cells, HDAC10 controls a MYC-dependent transcriptional induction of the DNA polymerase subunit POLD1. Consequently, pharmacological inhibition of HDAC10 causes DNA breaks and an accu ...[more]

PMID: 40301616

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