Dataset Information

Discovery of biomarker proteins in plasma extracellular vesicles from septic patients

ABSTRACT: Sepsis is a life-threatening condition induced by a dysregulated host response to infection, characterized clinically by systemic inflammation, hemodynamic instability, organ dysfunction, and high mortality. Plasma-derived extracellular vesicles (EVs) have been reported to play a role in mediating pathophysiological responses in sepsis, such as inflammation and coagulation. This study aims to identify biomarkers and elucidate pathways through differentially expressed proteins from plasma-derived EVs in septic patients.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma, Extracellular Vesicle

DISEASE(S): Septic Shock

SUBMITTER: chanhyun na

LAB HEAD: Chan Hyun Na

PROVIDER: PXD056258 | Pride | 2025-07-14

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	070224_sepsis_EV_plasma_chanhee_TK_TMT_1set_F01.raw	Raw
	070224_sepsis_EV_plasma_chanhee_TK_TMT_1set_F02.raw	Raw
	070224_sepsis_EV_plasma_chanhee_TK_TMT_1set_F03.raw	Raw
	070224_sepsis_EV_plasma_chanhee_TK_TMT_1set_F04.raw	Raw
	070224_sepsis_EV_plasma_chanhee_TK_TMT_1set_F05.raw	Raw

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Publications

Proteomic profiling of plasma extracellular vesicles identifies signatures of innate immunity, coagulation, and endothelial activation in septic patients.

Park Chanhee C Ryu Taekyung T Mohamed-Hinds Rashida R Kim Kyungdo K Kim Jin Hyeok JH Zou Lin L Williams Brittney B Na Chan Hyun CH Chao Wei W

Scientific reports 20250701 1

Plasma extracellular vesicles (EVs) are cell-derived lipid particles and reportedly play a role in sepsis pathogenesis. This study aimed to identify EV cargo proteins in septic patients and explore their association with key sepsis pathophysiology. Plasma EVs were subjected to Tandem Mass Tag (TMT)-based quantitative proteomic analysis. We identified 522 differentially expressed (DE) EV proteins in septic patients (n = 15) compared to the healthy controls (n = 10). The KEGG analysis of the DE pr ...[more]

PMID: 40596376

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