MS-based analysis of the interacting proteins of human topoisomerases (TOP1, TOP2A, TOP2B)

ABSTRACT: In this study, we used MS-based proteomics to identify the binding proteins of five human topoisomerases under four different conditions with treatment of CPT, ETO, HU, and NT. The proteomics result provide a quantitavie landscape of the binding partners of nearly all human topoisomerases. Several of the identitified binding proteins for each topoisomerase were validated by further experiments.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yun Xiong  

LAB HEAD: Junjie Chen

PROVIDER: PXD056277 | Pride | 2025-11-17

REPOSITORIES: Pride