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Proteomics of human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles

ABSTRACT: MSC-EV exerts their effects by transferring cargo components into target cells. Given that extracellular vesicles (EV) can deliver diverse cargo to recipient cells and elicit similar therapeutic effects, we investigate the cargo of both adipose-derived MSC-derived EV (AMSC-EV) and umbilical cord-derived MSC-derived EV (HUMSC-EV).As a crucial component of EV cargo, proteins are known to exert significant influence on EV functions. We performed a protein analysis of MSC-EV.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Huan Zhang

LAB HEAD: Robert Chunhua Zhao

PROVIDER: PXD056371 | Pride | 2025-05-07

REPOSITORIES: Pride

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			Action	DRS
	Aeox1.raw	Raw
	Aeox2.raw	Raw
	Aeox3.raw	Raw
	Huexo1.raw	Raw
	Huexo2.raw	Raw

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Publications

Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.

Zhang Huan H Xiao Xian X Wang Liping L Shi Xianhao X Fu Nan N Wang Shihua S Zhao Robert Chunhua RC

Signal transduction and targeted therapy 20241030 1

UVB radiation induces oxidative stress, DNA damage, and inflammation, leading to skin wrinkling, compromised barrier function, and an increased risk of carcinogenesis. Addressing or preventing photoaging may offer a promising therapeutic avenue for these conditions. Recent research indicated that mesenchymal stem cells (MSCs) exhibit significant therapeutic potential for various skin diseases. Given that extracellular vesicles (EV) can deliver diverse cargo to recipient cells and elicit similar ...[more]

PMID: 39472581

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