PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

ABSTRACT: Protein Serine Kinase H1 (PSKH1) was recently identified as a crucial factor in kidney development and is overexpressed in prostate, lung and kidney cancers. However, little is known about PSKH1’s regulation, leading to its classification as a “dark” kinase. Here, we used biochemistry and mass spectrometry to define PSKH1’s consensus substrate motif, protein interactors, and how interactors, including Ca2+ sensor proteins, promote or suppress activity.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Laura Gianni  

LAB HEAD: James M. Murphy

PROVIDER: PXD056543 | Pride | 2025-01-26

REPOSITORIES: Pride