Proteomics

Dataset Information

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Quantitative proteomic and lipidomic analysis of LNCaP and C4-2 cell lines during CRPC progression

ABSTRACT: Prostate cancer (PCa) is one of the most common cancers diagnosed in men in the world. The majority of patients develop resistant to androgen deprovation therapy, leading to castration-resistant PCa (CRPC). CRPC have a poorer prognosis and developing metastasis compared to hormone-sensitive PCa. To chracterize for new regulators of progression from HSPC to CRPC, LNCaP and C4-2 cells were selected as HSPC and CRPC, respectively. A comparative assessment of proein expression characteristics between two cells may provide insight into the regulatory landscape of CRPC.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Hyunchae Sim  

LAB HEAD: Sangkyu Lee

PROVIDER: PXD056553 | Pride | 2025-11-10

REPOSITORIES: Pride

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Dataset's files

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20220811_PCa_SILAC_1ug_120min_set1_F0.raw Raw
20220811_PCa_SILAC_1ug_120min_set2_F0.raw Raw
20220811_PCa_SILAC_1ug_120min_set3_F0.raw Raw
20220811_PCa_SILAC_500ng_60min_set1_F0.raw Raw
20220811_PCa_SILAC_500ng_60min_set1_F1.raw Raw
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Publications

Lipid Metabolic Reprogramming During Progression to Castration-resistant Prostate Cancer Identified by Quantitative Proteomics.

Sim Hyunchae H   Bae Subin S   Park Chai Won CW   Choi So Young SY   Liu Kwang-Hyeon KH   Lee Eun Hye EH   Kim Bum Soo BS   Chung Jae-Wook JW   Ha Yun-Sok YS   Lee Jun Nyung JN   Lee Wonhwa W   Kwon Tae Gyun TG   Lee Sangkyu S  

Cancer genomics & proteomics 20251101 6

<h4>Background/aim</h4>The progression of hormone-sensitive prostate cancer (HSPC) to castration-resistant prostate cancer (CRPC) as a result of resistance to androgen deprivation therapy (ADT) remains a major challenge in prostate cancer treatment.<h4>Materials and methods</h4>To explore the underlying mechanisms, we performed deep comparative proteomic profiling of HSPC and CRPC cell lines. LNCaP and C4-2 cell lines were cultured in isotopically labeled medium, combined, and digested, followed  ...[more]

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