Proteomics

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ROR2 drives right ventricular heart failure via disruption of proteostasis

ABSTRACT: This study assessed the impact of ROR2 expression on the global proteome using neonatal rat ventricular myocytes (NRVMs) using adenovirus to overexpress ROR2 vs control NRVMs with and without MG132 to block the proteasome to characterize proteasome-mediated clearance.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Heart, Cardiac Muscle Cell

SUBMITTER: Jonathan Edwards  

LAB HEAD: Jonathan Joseph Edwards

PROVIDER: PXD056556 | Pride | 2026-04-28

REPOSITORIES: Pride

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18098_tc_923_FA1_JM7876_Proteome_fractions.mzIdentML Mzid
18099_tc_923_FA9_JM7884_Proteome_fractions.mzIdentML Mzid
18100_tc_923_FA8_JM7883_Proteome_fractions.mzIdentML Mzid
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Publications

<h4>Background</h4>No therapies exist to reverse right ventricular failure (RVF), and the molecular mechanisms that drive RVF remain poorly studied. We recently reported that the developmentally restricted noncanonical WNT receptor ROR2 is upregulated in human RVF in proportion to severity of disease. Here we test mechanistic role of ROR2 in RVF pathogenesis.<h4>Methods</h4>ROR2 was overexpressed or knocked down in neonatal rat ventricular myocytes (NRVMs). ROR2-modified NRVMs were characterized  ...[more]

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