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Mass spectrometry analysis in human lung adenocarcinoma

ABSTRACT: Mass spectrometry analysis between the H1299 cells transfected with Vector or Flag-PSAT1

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung

SUBMITTER: Tianyu Han

LAB HEAD: Tianyu Han

PROVIDER: PXD056565 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Acetyl_Sites.txt	Txt
	GlyGly_Sites.txt	Txt
	Oxidation_Sites.txt	Txt
	Phospho_Sites.txt	Txt
	YAS202311150022_1_CTRL.raw	Raw

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1 - 5 of 17

Publications

Interplay between acetylation and ubiquitination controls PSAT1 protein stability in lung adenocarcinoma.

Liu Yuhan Y Xun Wenze W Zhao Tao T Huang Menglin M Sun Longhua L Wen Guilan G Kang Xiuhua X Wang Jianbin J Han Tianyu T

Communications biology 20241021 1

Serine is essential to maintain maximal growth and proliferation of cancer cells by providing adequate intermediate metabolites and energy. Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis. However, little is known about the mechanisms underlying PSAT1 degradation. We found that acetylation was the switch that regulated the degradation of PSAT1 in lung adenocarcinoma (LUAD). Deacetylation of PSAT1 on Lys51 by histone deacetylase 7 (HDAC7) enhanced the interact ...[more]

PMID: 39433916

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2022-01-03 | PXD012687 | Pride

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