Pig myocardial tissue quantitative proteomics

ABSTRACT: Proteomics study of the anthracycline-induced cardiotoxicity in in pigs with pre-existing left ventricular (LV) pressure overload. Large White pigs (2-month-old males and females) were used to induce LV pressure overload via supravalvular aortic stenosis (or sham operation). After 4 months, animals were subsequently exposed to low-risk cumulative doses of anthracyclines (doxorubicin, 5 weekly 1 mg/kg intravenous injections) or vehicle. A total of 16 pigs were divided in four groups: (1) healthy controls (no LV overload or anthracyclines), (2) Doxorubicin (Dox, no LV overload but anthracyclines), (3) Banding (LV overload without anthracyclines), and (4) Banding+Doxorubicin (LV overload plus anthracyclines). A high-throughput quantitative proteomic analysis was performed in myocardial tissue.

INSTRUMENT(S):

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Heart

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Inmaculada Jorge  

LAB HEAD: Jesús María Vázquez Cobos

PROVIDER: PXD056684 | Pride | 2026-02-05

REPOSITORIES: Pride