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Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer

ABSTRACT: To understand the transcriptomic, genomic and proteomics changes between HER2 overexpressingcells and those that have become resistant to lapatinib

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Breast

DISEASE(S): Breast Cancer

SUBMITTER: Vinothini Rajeeve

LAB HEAD: Professor Pedro Cutillas

PROVIDER: PXD056848 | Pride | 2025-11-17

REPOSITORIES: Pride

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			Action	DRS
	QE1_MS_579_TP_Sample_Lapatinib_4.raw	Raw
	QE1_MS_579_TP_Sample_Lapatinib_4_calibrated.mzML	Mzml
	QE1_MS_579_TP_Sample_Lapatinib_4_calibrated.mzid.gz	Mzid
	QE1_MS_579_TP_Sample_Lapatinib_5.raw	Raw
	QE1_MS_579_TP_Sample_Lapatinib_5_calibrated.mzML	Mzml

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Publications

Integrative proteo-genomic profiling uncovers key biomarkers of lapatinib resistance in HER2-positive breast cancer.

Steggall J J Rajeeve V V Al-Subaie N N Naeem A A Ikram A A Naeem A A Hayat A A

British journal of cancer 20250913 10

<h4>Introduction</h4>Drug resistance is a major obstacle to the long-term effectiveness of cancer therapies. Approximately 70% of breast cancer patients relapse after 5 years of treatment, and the lack of biomarkers associated with drug resistance translates to poor prognosis in the clinic. Previous research has utilised omics approaches to uncover biomarkers driving drug resistance, with a strong emphasis on genetic mutations.<h4>Methods</h4>Here, we identified a nine-marker signature associate ...[more]

PMID: 40946111

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