Proteomics

Dataset Information

0

Proteome sequencing for the colon tissues of mice with ckmt1 knockout


ABSTRACT: We here performed a proteomics study on the colon tissues of ckmt1 KOIEC or. WT (flox+/+) mice after DSS treatment for 8 days (n=3). KOIEC mice (Ckmt1flox/flox, Vil-Cre) means mice with intestinal epithelial conditional knockout (C57BL/6J). Cre-negative Ckmt1 flox/flox littermates were used as controls. Group 1: DSSCKO (Ckmt1flox/flox, Vil-Cre) Group 2: DSSflox (Cre-negative Ckmt1 flox/flox littermates)

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Colon

SUBMITTER: Zhijie Wang  

LAB HEAD: Zhijie Wang

PROVIDER: PXD057053 | Pride | 2025-05-07

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
XA01434LQ.zip Other
XA01434LQ_DSSCKO1.raw Raw
XA01434LQ_DSSCKO2.raw Raw
XA01434LQ_DSSCKO3.raw Raw
XA01434LQ_DSSflox1.raw Raw
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Publications

CKMT1 deficiency contributes to mitochondrial dysfunction and promotes intestinal epithelial cell apoptosis via reverse electron transfer-derived ROS in colitis.

Wang Zhijie Z   Wu Haicong H   Chang Xin X   Song Yihang Y   Chen Yan Y   Yan Ziwei Z   Gu Lun L   Pang Ruxi R   Xia Tian T   He Zixuan Z   Li Zhaoshen Z   Wang Shuling S   Bai Yu Y  

Cell death & disease 20250315 1


Mitochondrial dysfunction contributes to the pathogenesis of ulcerative colitis (UC). As a mitochondrial isozyme of creatine kinases, which control energy metabolism, CKMT1 is thought to be a critical molecule in biological processes. However, the specific role of CKMT1 in intestinal inflammation remains largely unknown. Here, we observed markedly decreased CKMT1 expression in the colon tissues of UC patients and dextran sodium sulfate (DSS)-induced colitis mice. We generated intestinal epitheli  ...[more]

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