Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Colon
SUBMITTER: Zhijie Wang
LAB HEAD: Zhijie Wang
PROVIDER: PXD057053 | Pride | 2025-05-07
REPOSITORIES: Pride
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XA01434LQ.zip | Other | |||
XA01434LQ_DSSCKO1.raw | Raw | |||
XA01434LQ_DSSCKO2.raw | Raw | |||
XA01434LQ_DSSCKO3.raw | Raw | |||
XA01434LQ_DSSflox1.raw | Raw |
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Cell death & disease 20250315 1
Mitochondrial dysfunction contributes to the pathogenesis of ulcerative colitis (UC). As a mitochondrial isozyme of creatine kinases, which control energy metabolism, CKMT1 is thought to be a critical molecule in biological processes. However, the specific role of CKMT1 in intestinal inflammation remains largely unknown. Here, we observed markedly decreased CKMT1 expression in the colon tissues of UC patients and dextran sodium sulfate (DSS)-induced colitis mice. We generated intestinal epitheli ...[more]