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Protein complex S100B-Abeta(1-40)

ABSTRACT: Project aims at characterisation of the structural dynamics of complex partners in isolation and in complex in different composition of metal ions, Ca, Zn, Cu to establish the impact of metal ions and peptide on S100B stuctural features and its oligomerisation status..

INSTRUMENT(S): Synapt MS

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain, Hippocampal Neuron

DISEASE(S): Alzheimer's Disease 1

SUBMITTER: Agata Malinowska

LAB HEAD: Michał Dadlez

PROVIDER: PXD057057 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	AbetaCu_S100BZn.csv	Csv
	AbetaCu_S100BZn_S100BCa.csv	Csv
	AbetaCu_S100BZn_S100B_Ca.DnX	Other
	LZ_240613_S100b_seq1_IA_final_peptide.csv	Csv
	LZ_240614_ab1_40seq1_IA_final_peptide.csv	Csv

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1 - 5 of 22

Publications

HRaDeX: R Package and Web Server for Computing High-Resolution Deuterium Uptake Rates for HDX-MS Data.

Puchała Weronika W Kistowski Michał M Zhukova Liliya L Burdukiewicz Michał M Dadlez Michał M

Journal of proteome research 20250319 4

Hydrogen-deuterium exchange monitored by mass spectrometry (HDX-MS) is a well-established and powerful technique used to study protein dynamics and stability by capturing local and global unfolding events in protein structures. However, in this technique, obtaining region-specific information requires proteolytic digestion that breaks the protein into peptide fragments, causing the HDX data to reflect averages over these fragments rather than individual amino acids. We propose a new computationa ...[more]

PMID: 40105417

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