Dataset Information

Betulinic acid production with engienered Scerevisiae CENPK BA6

ABSTRACT: Betulinic acid production in fed-batch fermentation of S. cerevisiae engineered for the recombinant production of this triterpenoid halts after approx. 100 hours. To investiate the reasons for this phenomenon,we performed proteomics analyses on cells sampled at various time point of the fermentations, which were run with either glucose or ethanol as the carbon source.

INSTRUMENT(S):

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) Saccharomyces Cerevisiae

SUBMITTER: Birgitta Ebert

LAB HEAD: Birgitta Ebert

PROVIDER: PXD057071 | Pride | 2025-05-07

REPOSITORIES: Pride

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Publications

Exploration of In Situ Extraction for Enhanced Triterpenoid Production by Saccharomyces cerevisiae.

Dianat Mariam M Straaten Sarah S Maritato Aldo A Wibberg Daniel D Busche Tobias T Blank Lars M LM Ebert Birgitta E BE

Microbial biotechnology 20241201 12

Plant-derived triterpenoids are in high demand due to their valuable applications in cosmetic, nutraceutical, and pharmaceutical industries. To meet this demand, microbial production of triterpenoids is being developed for large-scale production. However, a prominent limitation of microbial synthesis is the intracellular accumulation, requiring cell disruption during downstream processing. Destroying the whole-cell catalyst drives up production costs and limits productivity and product yield per ...[more]

PMID: 39696809

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