Dataset Information

Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice

ABSTRACT: The comparative proteomic analysis was elucidated to explore the effects of Ankfy1 in the cerebellum.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Rong Fu

LAB HEAD: Rong Fu

PROVIDER: PXD057098 | Pride | 2025-07-14

REPOSITORIES: Pride

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Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice.

Fu Rong R Ding Man M Yin Tong T Zheng Linlin L Liu Yue Y Yu Hang H Zhou Rumeng R Lu Zuneng Z

Scientific reports 20250701 1

Ankyrin repeat and FYVE domain containing 1 (ANKFY1) is an indispensable protein in the development of cerebellar Purkinje cells. Our preliminary study revealed that its absence caused progressive spastic ataxia, accompanied by the loss of Purkinje cells in mice. Here, we generated Ankfy1-floxed (Ankfy1<sup>f/f</sup>) mice, in which conditional inactivation of the Ankfy1 gene was achieved specifically in cerebellar Purkinje cells via crossing with a transgenic mouse strain expressing Cre recombi ...[more]

PMID: 40594855

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Dataset Information

Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice

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Publications

Identification of spastic ataxia-related proteins via comparative proteomic analysis of the cerebellum of conditional Ankfy1 knockout mice.

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