Dataset Information
Finding the LC3-interactors in senescent human A549 cells during influenza A virus infection
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Influenza
SUBMITTER: 
Zhimin Jiang
LAB HEAD: Zhimin Jiang
PROVIDER: PXD057110 | Pride | 2025-09-29
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| F003456.fasta | Fasta | |||
| F003456.mgf | Mgf | |||
| F003456.mzid.gz | Mzid | |||
| F003456.xml | Xml | |||
| H1___data_20231123_F003456_dat_rf_reportbuilder.xml | Xml |
Items per page: 1 - 5 of 6 |
Publications
ApoD mediates age-associated increase in vulnerability to influenza virus infection.
Proceedings of the National Academy of Sciences of the United States of America 20250911 37
Influenza A virus (IAV) infection causes significantly greater morbidity and mortality in the elderly population, but the molecular mechanisms in the aging process responsible for severe infection remain unclear. In this study, we found that increased severity in IAV infection and reduced innate immune response correlated with extensive mitophagy in senescent human cells and in the lung of aged mice. Apolipoprotein D (ApoD) was identified as strongly elevated in the lungs and sera of aged human ...[more]
