Proteomics

Dataset Information

0

Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used For Liquid Biopsy Based Diagnostics

ABSTRACT: Tumor-derived extracellular vesicles (TEVs) play a crucial role in cancer progression, metastasis and therapy resistance but their distinct profiles across different cancer stages and molecular subtypes remain underexplored. This study analyzed TEVs from epithelial (CMS2) and mesenchymal (CMS4) subtypes of colorectal cancer (CRC) using six cell lines and clinical samples. Investigation of the cargo of vesicles secreted by the two subtypes revealed significant differences in mRNA, miRNA, and protein profiles between the two subtypes. Notably, CMS2 predominantly secreted smaller, Tetraspanin-8 (TSPAN8) enriched EVs, while CMS4 produced both larger and smaller EVs, enriched in TSPAN4. This underscores the complexity of vesicle heterogeneity between these subtypes. Additionally, we assessed miRNA profiles from plasma-derived bulk TEVs in CRC patients.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Thang Pham  

LAB HEAD: Connie Jimenez

PROVIDER: PXD057149 | Pride | 2025-11-10

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
QE3_220531_OPL1039_LHB_CRC_CMS_EV_A.raw Raw
QE3_220531_OPL1039_LHB_CRC_CMS_EV_A_20220609091719.raw Raw
QE3_220531_OPL1039_LHB_CRC_CMS_EV_B.raw Raw
QE3_220531_OPL1039_LHB_CRC_CMS_EV_C.raw Raw
QE3_220531_OPL1039_LHB_CRC_CMS_EV_D.raw Raw
Items per page:
1 - 5 of 17
altmetric image

Publications

Tumour-derived extracellular vesicles (TEVs) play a crucial role in cancer progression, metastasis and therapy resistance but their distinct profiles across different cancer stages and molecular subtypes remain underexplored. This study initially analysed TEVs from all CMS subtypes in colorectal cancer (CRC) cells and continued focusing on the epithelial (CMS2) and mesenchymal (CMS4) subtypes using six cell lines and clinical samples. Investigation of the cargo of vesicles secreted by the two su  ...[more]

Similar Datasets

Transcriptomics Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used For Liquid Biopsy Based Diagnostics [RNA-seq plasma]
2025-10-15 | GSE280384 | GEO
Genomics Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used For Liquid Biopsy Based Diagnostics [miRNA-seq]
2025-10-15 | GSE280254 | GEO
Genomics Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used For Liquid Biopsy Based Diagnostics [miRNA-seq plasma]
2025-10-15 | GSE280383 | GEO
Transcriptomics Mesenchymal Colorectal Cancers Secrete Vesicles With Unique Cargo That Can Be Used For Liquid Biopsy Based Diagnostics [RNA-seq]
2025-10-15 | GSE280367 | GEO
Proteomics AKT dependent Notch3 activation drives tumor progression in a model of mesenchymal colorectal cancer subtype
2021-09-08 | PXD014778 | Pride
Transcriptomics Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [primary cell lines AMC/Palermo]
2017-12-01 | GSE100549 | GEO
Transcriptomics Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [cell line panel]
2017-12-01 | GSE100478 | GEO
Transcriptomics Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [patient tumors and PDX models]
2017-12-01 | GSE100480 | GEO
Transcriptomics Consensus Molecular Subtypes of colorectal cancer are recapitulated in in vitro and in vivo models [primary cell lines Hubrecht Institute]
2017-12-01 | GSE100479 | GEO
Transcriptomics AKT dependent NOTCH3 activation drives tumor progression in a model of mesenchymal colorectal cancer subtype [2016]
2020-07-29 | GSE136218 | GEO