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Proteomic anlaysis of bone marrow from Dmp1Cre.Socs3f/f.Csf3r-/- mice

ABSTRACT: To identify the mechanisms regulating osteoblasts and osteoclasts in Dmp1Cre.Socs3f/f.Csf3r-/- mice, we performed a proteomic analysis of their bone marrow compared to littermate Dmp1Cre.Socs3f/f controls.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Bone Marrow

SUBMITTER: Benjamin Parker

LAB HEAD: Benjamin Parker

PROVIDER: PXD057179 | Pride | 2026-02-02

REPOSITORIES: Pride

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			Action	DRS
	20220410_172908_220404_Sims_Marrow.zip	Other
	220325_BenP_Eclipse_BP-4060_A3.raw	Raw
	220325_BenP_Eclipse_BP-4060_B3.raw	Raw
	220325_BenP_Eclipse_BP-4060_C3.raw	Raw
	220325_BenP_Eclipse_BP-4060_D3.raw	Raw

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Publications

Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone.

Isojima Tsuyoshi T Crimeen-Irwin Blessing B McGregor Narelle E NE Chai Ryan C RC Poulton Ingrid J IJ Walker Emma C EC Dutt Mriga M Parker Benjamin L BL Sims Natalie A NA

Blood 20250901 11

<h4>Abstract</h4>In inflammation, circulating neutrophils indirectly damage the skeleton by inducing formation of bone-resorbing osteoclasts. However, neutrophil progenitors in marrow have no known physiological function. A bone-protective role for the neutrophil lineage was recently suggested when a profound defect in bone structure was observed in mice with neutropenia due to granulocyte colony-stimulating factor deletion coupled with STAT3 hyperactivation in bone cells. Here, we tested the ex ...[more]

PMID: 40540748

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