Dataset Information

Mass-spectrometry analysis of secretome and extracellular vesicles derived from lung and colorectal cell lines

ABSTRACT: We conducted a proteomic analysis of secretome and EV samples isolated from the conditioned medium of lung cancer LC (A549, NCI-H23, and NCI-H460) and CRC (Caco2, HCT116, and HT-29) cell line models.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell, Cell Culture

DISEASE(S): Lung Cancer,Colon Cancer

SUBMITTER: Svetlana Novikova

LAB HEAD: Victor Zgoda

PROVIDER: PXD057205 | Pride | 2025-05-07

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	220124LSB_Exosomes01.raw	Raw
	220124LSB_Exosomes01_20240122185533.raw	Raw
	220124LSB_Exosomes01_20240122203147.raw	Raw
	220124LSB_Exosomes02.raw	Raw
	220124LSB_Exosomes02_20240123004819.raw	Raw

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Publications

Secretome and Proteome of Extracellular Vesicles Provide Protein Markers of Lung and Colorectal Cancer.

Soloveva Natalia N Novikova Svetlana S Farafonova Tatiana T Tikhonova Olga O Zgoda Victor V

International journal of molecular sciences 20250125 3

Colorectal cancer (CRC) and lung cancer (LC) are leading causes of cancer-related mortality, highlighting the need for minimally invasive diagnostic, prognostic, and predictive markers for these cancers. Proteins secreted by a tumor into the extracellular space directly, known as the tumor secretome, as well as proteins in the extra-cellular vesicles (EVs), represent an attractive source of biomarkers for CRC and LC. We performed proteomic analyses on secretome and EV samples from LC (A549, NCI- ...[more]

PMID: 39940785

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