Dataset Information

Assessment of the epithelial/mesenchymal phenotype of pancreatic cancer cells based on data-independent acquisition – mass spectrometry.

ABSTRACT: Based on data-independent acquisition (DIA)-mass spectrometry (MS), we assessed the epithelial/mesenchymal phenotype of three pancreatic cancer cell lines: CAPAN-1, PANC-1 and MIA PaCa-2 in 2D cell culture.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Malignant Cell, Cell Culture

DISEASE(S): Pancreatic Ductal Carcinoma

SUBMITTER: Lode Denolf

LAB HEAD: Kris Gevaert

PROVIDER: PXD057259 | Pride | 2025-11-10

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	AllSamp_report.tsv	Tabular
	B2037_Bp_Neo7_CMB-1197_KRGEV_NeleVandenbussche_SG_DIA-P1.raw	Raw
	B2039_Bp_Neo7_CMB-1197_KRGEV_NeleVandenbussche_SG_DIA-P2.raw	Raw
	B2041_Bp_Neo7_CMB-1197_KRGEV_NeleVandenbussche_SG_DIA-P3.raw	Raw
	B2043_Bp_Neo7_CMB-1197_KRGEV_NeleVandenbussche_SG_DIA-P4.raw	Raw

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Publications

EMT-associated bias in the Parsortix® system observed with pancreatic cancer cell lines.

Vandenbussche Nele N Imschoot Renske R Lintermans Béatrice B Denolf Lode L Taminau Joachim J Fieuws Charlotte C Berx Geert G Gevaert Kris K Claes Kathleen B M KBM

Molecular oncology 20250618 11

Pancreatic cancer has a 5-year survival rate of 12%, highlighting the need for reliable biomarkers for early detection and disease monitoring. Circulating tumor cells (CTCs) have emerged as a promising biomarker, yet their detection remains challenging. This study evaluates the Parsortix® system, a microfluidic device that enriches CTCs based on size and deformability, using pancreatic cancer cell lines. As increasing evidence indicates that during epithelial-to-mesenchymal transition (EMT) a ce ...[more]

PMID: 40531655

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