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Human bronchoalveolar lavage fluid LC-MSMS

ABSTRACT: Exploring the proteomic changes in patients with varying degrees of pneumoconiosis

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Bronchoalveolar Lavage

SUBMITTER: Pei Pei

LAB HEAD: Peipei Wang

PROVIDER: PXD057353 | Pride | 2025-05-07

REPOSITORIES: Pride

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Publications

Proteomics and Metabolomics Analyses Reveal a Dynamic Landscape of Coal Workers' Pneumoconiosis: An Insight into Disease Progression.

Wei Yangyang Y Jia Zhenzhen Z Ma Jing J Zhang Wei W Li Hui H Wu Juan J Wang Xiaojing X Yu Xiao X Shi Yiwei Y Kong Xiaomei X Pang Min M

Journal of proteome research 20250304 4

Coal worker's pneumoconiosis (CWP) is characterized by chronic inflammation and pulmonary fibrosis. The key factor contributing to the incurability of CWP is the unclear pathogenesis. This study explored the characteristic changes in proteomics and metabolomics of early and advanced CWP patients through proteomics and metabolomics techniques. Proteomics identified proteins that change with the progression of CWP, with significant enrichment in the TGF-β signaling pathway and autoimmune disease p ...[more]

PMID: 40036136

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