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Proteomic and Phosphoproteomic Signatures of Aging Mouse Liver

ABSTRACT: We conducted a comparative proteomic and phosphoproteomic analysis of aging mice livers from young adults (3-4 months) and old (19-21 months) mice to identify age-related changes of liver proteins and phosphosites linked to various metabolic pathways.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Rodrigo Mohallem

LAB HEAD: Uma K Aryal

PROVIDER: PXD057407 | Pride | 2025-06-30

REPOSITORIES: Pride

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			Action	DRS
	GlobalResults.zip	Other
	PPF-RMF-1777-2_Liver_Trypsin_Global_Adult-2_1_A.raw	Raw
	PPF-RMF-1777-2_Liver_Trypsin_Global_Adult-3_1_A.raw	Raw
	PPF-RMF-1777-2_Liver_Trypsin_Global_Adult-4_1_A.raw	Raw
	PPF-RMF-1777-2_Liver_Trypsin_Global_Adult-5_1_A.raw	Raw

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Proteomic and phosphoproteomic signatures of aging mouse liver.

Mohallem Rodrigo R Schaser Allison J AJ Aryal Uma K UK

GeroScience 20250314 3

The liver is a metabolic powerhouse, crucial for regulating carbohydrates, fats, and protein metabolism. In this study, we conducted a comparative proteomic and phosphoproteomic analysis of aging mouse livers from young adults (3-4 months) and old (19-21 months) mice to identify age-related changes in liver proteins and phosphosites, which were linked to various metabolic pathways. In old mice, proteins associated with the "complement and coagulation cascade," "age-rage signaling in diabetic com ...[more]

PMID: 40087212

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