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Taurine inhibits apolipoprotein E4 aggregation

ABSTRACT: ApoE4 is the first genetic risk factor for Alzheimer's disease. Its aberrant aggregation can be inhibited by tramiprosate (TMP) and its metabolite 3-sulfopropanoic acid (SPA), along with their impact on the transcription of genes, expression of proteins, and production of lipids. Taurine (TAU) is a close chemical analogue of TMP which has already proven beneficial effects against aging. Combining static light scattering, hydrogen-deuterium exchange mass spectrometry, molecular dynamics with analysis of Markov states, and investigation of cerebral organoids, we compare the effects of TMP, SPA, and TAU on ApoE4 aggregation, and organoid transcriptomics and proteomics. We found that TAU has a similar effect as SPA in inhibiting ApoE4 aggregation and correcting the pathophysiological phenotype of ApoE4 towards that of ApoE3 in cerebral organoids. These findings suggest that taurine may have potential as a therapeutic agent for Alzheimer's disease, particularly in individuals carrying the ApoE4/E4 genotype

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Naina Verma

LAB HEAD: Prof. Lenka Hernychova

PROVIDER: PXD057427 | Pride | 2026-07-09

REPOSITORIES: Pride

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			Action	DRS
	ApoE3_ND_3.zip	Other
	ApoE3_SPA_120s_1.zip	Other
	ApoE3_SPA_120s_2.zip	Other
	ApoE3_SPA_120s_3.zip	Other
	ApoE3_SPA_1800s_1.zip	Other

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