Heterologous production of phosphorylated casein

ABSTRACT: The demand for milk proteins is on the rise, but sustainability concerns dictate a reduction of animal-based agriculture. Microbial cell factories can be a viable alternative, but their inability to phosphorylate recombinant caseins is a major bottleneck, since phosphorylation is needed for calcium binding and functionality. We propose a solution based on engineered bacterial protein kinases, which results in microbially produced caseins with the correct phosphorylation pattern and functional properties.

INSTRUMENT(S):

ORGANISM(S): Escherichia Coli

SUBMITTER: Carsten Jers  

LAB HEAD: Ivan Mijakovic

PROVIDER: PXD057429 | Pride | 2025-07-04

REPOSITORIES: Pride