What does next generation Mass Spectrometry offer for proteomics? A comprehensive platform comparison

ABSTRACT: Next-generation mass spectrometry platforms (Orbitrap Astral, timsTOF Ultra) are reshaping proteomics by enhancing analytical depth and sensitivity. We compared these platforms against Orbitrap Exploris 480 using neonatal mouse lung tissue from a bronchopulmonary dysplasia model (n=12), employing four acquisition strategies: Exploris 480 DDA/DIA, Astral HR-DIA, and timsTOF Ultra DIA-PASEF.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung

DISEASE(S): Bronchopulmonary Dysplasia

SUBMITTER: Filipa Blasco Tavares Pereira Lopes  

LAB HEAD: Mark Chance

PROVIDER: PXD057442 | Pride | 2026-04-02

REPOSITORIES: Pride